• AMC documents
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  • AMC design phase

    20 April 2009

    Consultation and Advisory Process

    The World Bank, The GAVI Alliance and the AMC Donor Committee sought stakeholder input on the planning and design of the pilot AMC through expert groups, consultations, meetings and roundtables. The aim was to incorporate into the design of the AMC the recommendations of economists, global health experts, medical practitioners and scientists from developing and industrialized countries as well as manufacturers and civil society organizations. 

    • Total pages:
    • 44
    • Publisher:
    • AMC

    01 April 2008

    Economic Expert Group (EEG) Report

    A report prepared by the Economic Expert Group convened by the GAVI Alliance to provide guidance to the pneumococcal AMC donors about key design decisions using new information available from industry consultations, demand forecasts and modeling of returns to industry under various demand and price scenarios.

    • Total pages:
    • 39
    • Publisher:
    • AMC

    11 March 2007

    EEG Donor response

    In May 2007, the AMC Donor Committee constituted an independent Economic Expert Group (EEG) to advise on the initial AMC design. This document is the donors' response to the EEG report.

    • Total pages:
    • 4
    • Publisher:
    • AMC

    10 July 2008

    Implementation Working Group (IWG) Report

    This report presents the group’s operational recommendations to inform donors’ decisions on AMC design and implementation. It is intended as an addendum to the EEG report, rather than a stand-alone document; therefore, readers will find a number of cross-references.

    • Author(s):
    • AMC Implementation Working Group (IWG)
    • Total pages:
    • 45
    • Publisher:
    • AMC Implementation Working Group (IWG)

    28 February 2006

    Independent Expert Committee Membership

    List of members of the Indepedent Expert Committee meeting in Paris, France held the 27-28 February 2008.

    • Total pages:
    • 1
    • Publisher:
    • AMC

    29 June 2007

    Independent Expert Committee Recommendation for AMC Pilot

    The Independent Expert Committee was convened to assess which of the six vaccines included in the Tremonti report would be most suitable for the pilot AMC.

    • Total pages:
    • 4
    • Publisher:
    • AMC

    10 July 2008

    IWG Joint Donor Statement

     In February 2007, a collective US$1.5 billion for a pilot Advance Market Commitment (AMC) against pneumococcal disease was pledged by the Governments of Italy, the UK, Canada, Russia and Norway, and the Bill & Melinda Gates Foundation. The report recommends the terms on which the AMC will be offered to help developing countries buy new, more effective pneumococcal vaccines.

    • Total pages:
    • 2
    • Publisher:
    • AMC

    07 September 2006

    Pilot Proposal

    Pilot proposal for the Advance Market Committment to demonstrate both the feasability of the AMC mechanism and its impact on accelerating vaccine development, production scale-up and introduction.

    • Total pages:
    • 15
    • Publisher:
    • AMC

    09 November 2006

    Second Donor Working Group - Agenda London, November 2006

    Agenda of the second meeting of the Technical Working Group in London on 9 November 2006.

    • Total pages:
    • 1
    • Publisher:
    • AMC

    09 November 2006

    Second Donor Working Group - Framework

    Framework document for the pilot AMC for pneumococcal vaccines.

    • Total pages:
    • 56
    • Publisher:
    • GAVI

    09 November 2006

    Second Donor Working Group - Participants London, November 2006

    List of participants at the 2nd meeting of the AMC working group.

    • Total pages:
    • 1
    • Publisher:
    • AMC

    09 November 2006

    Second Donor Working Group - Summary London, November 2006

    Summary of the second meeting of the Technical Working Group on AMC held in London on 9 November 2006.

    • Total pages:
    • 1
    • Publisher:
    • AMC

  • Annual Reports

    31 March 2010

    2010 Pneumococcal AMC Annual Report

    This progress report presents an overview of the activities linked to the implementation of the pneumococcal AMC since the signature of the legal agreements on 12 June 2009 up until 31 March 2010. It was developed by the AMC Secretariat at GAVI, in collaboration with the World Bank and UNICEF’s Supply Division, and was approved by the Independent Assessment Committee on 13 April 2010.

    • Total pages:
    • 38
    • Publisher:
    • AMC

    01 April 2011

    2011 Pneumococcal AMC Annual Report

    The 2011 Pneumococcal AMC Annual Report gives an overview of all activities linked to the implementation of the pilot Advance Market Commitment from 1 April 2010 to 31 March 2011.

    • Author(s):
    • GAVI Alliance Secretariat, World Bank, UNICEF Supply Division, Independent Assessment Committee
    • Total pages:
    • 37

    01 June 2012

    2012 Pneumococcal AMC Annual Report

    The 2012 Pneumococcal AMC Annual Report gives an overview of all activities linked to the implementation of the pilot Advance Market Commitment from 1 April 2011 to 31 March 2012. It provides an extensive description of the first achievements of this innovative initiative: the first introductions of pneumococcal vaccines in GAVI countries.

    • Author(s):
    • AMC Secretariat at GAVI, World Bank and UNICEF Supply Division
    • Total pages:
    • 27

    29 April 2013

    2013 Pneumococcal AMC Annual Report

    The 2013 Pneumococcal AMC Annual Report gives an overview of the activities linked to the implementation of the pilot Advance Market Commitment from 1 April 2012 to 31 March 2013. During this period a third tender was issued in response to the high level of country demand and eight countries introduced pneumococcal vaccines procured through the AMC, taking the total to 24 introductions by March 2013.

    • Author(s):
    • Developed by the AMC Secretariat at GAVI, in collaboration with UNICEF Supply Division and the World Bank, approved by the Independent Assessment Committee on 25 April 2013
    • Total pages:
    • 35

  • Background documents

    17 March 2008

    All-Party Parlimentary Group on Pneumococcal Disease Report

    This report summarises the results of the All-Party Parliamentary Group for Pneumococcal Disease Prevention in the Developing World (APPG) inquiry into pneumococcal disease in the developing world.

    • Total pages:
    • 40
    • Publisher:
    • All-Party Parliamentary Group on Pneumococcal Disease Prevention in the Developing World

    11 March 2005

    Making markets for vaccines: Ideas to action

    This report discusses the need to invest more in vaccines and the proposal of making a commitment in advance to buy vaccines if and when they are developed to create incentives for industry to increase investment in research and development.

    • Author(s):
    • Center for Global Development: Michael Kremer, Ruth Levine and Owen Barder
    • Total pages:
    • 129
    • Publisher:
    • AMC

    08 February 2007

    Pneumococcal Disease - The Human Face

    Stories of three young children in Africa and Asia and their fight against pneumococcal disease.

    • Total pages:
    • 2
    • Publisher:
    • pneumoADIP

    08 February 2007

    Pneumococcal Disease Background

    Streptococcus pneumoniae are bacteria that are frequently found in the upper respiratory tract of healthy children and adults. These bacteria, however, can also cause a range of infections – from relatively mild ear infections to fatal pneumonia, meningitis, and sepsis. Serious pneumococcal infections can occur throughout life, but children under two years old and the elderly are at highest risk. 

    • Total pages:
    • 1
    • Publisher:
    • pneumoADIP

    02 December 2005

    Tremonti Report to the G8 Finance Ministers

    Background papers to the AMC providing the analysis underpinning Minister Giulio Tremonti's Report to the G8 Finance Ministers Advanced Market Commitments to Vaccines.

    • Total pages:
    • 63
    • Publisher:
    • AMC

  • Fact sheets

    23 November 2012

    Factsheet: Advance Market Commitment

    Learn about Advance Market Commitment, including the pilot AMC for pneumococcal vaccines.

    • Author(s):
    • GAVI, World Bank
    • Total pages:
    • 6

  • Independent Assessment Committee (IAC)

    12 November 2009

    IAC Members

    List of IAC members.

    • Total pages:
    • 1
    • Publisher:
    • AMC

    27 October 2009

    IAC Selection Process

    The selection process for Independent Assessment Committee (IAC) members is administered by the GAVI Alliance Secretariat, in its role as AMC Secretariat. Evaluation of candidates is conducted by a selection panel composed of five international leaders on global health issues.

    • Author(s):
    • GAVI Alliance
    • Total pages:
    • 1
    • Publisher:
    • AMC

    16 April 2010

    Minutes from AMC Eligibility Determination Meeting April 2010

    Minutes from AMC Eligibility Determination Meeting held in London, UK on 16 April 2010.

    • Total pages:
    • 4
    • Publisher:
    • AMC

    11 December 2008

    Minutes from December 2008 meeting

    Minutes from the AMC Independent Assessment Committee (IAC) meeting on 11 December 2008.

    • Total pages:
    • 2
    • Publisher:
    • AMC

    03 November 2008

    Minutes from November 2008 meeting

    Minutes from the AMC Independent Assessment Committee (IAC) meeting on 3 November 2008.

    • Total pages:
    • 3
    • Publisher:
    • AMC

  • Inflation Review Application Process

    29 July 2010

    Pneumococcal AMC Inflation Review Application Process

    The process for manufacturers interested in submitting an Inflation Review Application.

    • Total pages:
    • 3
    • Publisher:
    • AMC

  • Legal documents

    07 March 2011

    AMC deed of amendment and restatement

    AMC deed of amendment and restatement relating to the Advance Market Commitment for pneumococcal vaccines offer agreement, IAC Charter & bylaws and procedures memorandum orginally dated 12 June 2009.

    • Total pages:
    • 110
    • Publisher:
    • AMC

    09 March 2011

    AMC Legal Agreements: detailed list of modifications

    List of modifications to the AMC legal agreements.

    • Total pages:
    • 2
    • Publisher:
    • AMC

    03 July 2009

    Master Definitions Agreement

    Master definitions schedule relating to the AMC for pneumococcal vaccines.

    • Total pages:
    • 20
    • Publisher:
    • AMC

    07 March 2011

    Revised AMC offer agreement

     

    Offer agreement relating to the Advance Market Commitment for pneumococcal vaccines.

    • Total pages:
    • 50
    • Publisher:
    • GAVI

    07 March 2011

    Revised AMC procedures memorandum

    This Procedures Memorandum describes the procedures that would be applicable to any AMC.

    • Total pages:
    • 26
    • Publisher:
    • AMC

    11 March 2009

    Revised Independent Assessment Committee charter and bylaws

    The charter and bylaws of the Independent Assessment Committee (IAC).

    • Total pages:
    • 16
    • Publisher:
    • AMC

  • Monitoring and Evaluation

    29 October 2010

    AMC Baseline Study

    The AMC Baseline Study presents an innovative new approach to public health funding as a way of stimulating and accelerating the development and manufacture of vaccines for developing countries.

    • Total pages:
    • 177
    • Publisher:
    • The Swiss Centre for International Health

    13 November 2008

    Monitoring and Evaluability Study

    The report was commissioned by the Monitoring & Evaluation Subgroup of the AMC Donor Committee in August 2007. The monitoring and evaluation proposals contained in this report have been designed to enable the effectiveness, efficiency and eventual impact of this pilot AMC to be measured over time and to assist with its effective management.

    • Total pages:
    • 110
    • Publisher:
    • AMC

    30 September 2011

    Pneumococcal Advance Market Commitment: Lessons Learnt on Disease and Design Choices and Processes

    This document describes early lessons learnt on the selection of a target disease, on core design choices, and on processes related to the pilot Advance Market Commitment (AMC) for pneumococcal vaccines. While ongoing monitoring and evaluations scheduled for the coming years will provide further information about the value of the Pneumo AMC, this document highlights some of the key lessons to date and aims to provide a starting point to inform discussions about the potential applications of the AMC concept to other vaccines or health and non-health interventions.

    • Author(s):
    • Tania Cernuschi, Eliane Furrer, Susan McAdams, Andrew Jones, Johanna Fihman, Nina Schwalbe, GAVI Secretariat
    • Total pages:
    • 46

  • Remaining offer amount

    16 June 2010

    Remaining AMC offer amount 2010

    The official formal notification of the remaining AMC Offer Amount.

    • Author(s):
    • International Bank for Reconstruction and Development (World Bank)
    • Total pages:
    • 1

    16 June 2011

    Remaining AMC offer amount: June 2011

    The official formal notification of the remaining AMC Offer Amount.

    • Author(s):
    • International Bank for Reconstruction and Development (IBRD)
    • Total pages:
    • 1

    19 June 2012

    Remaining AMC offer amount: June 2012

    Remaining AMC offer amount: June 2012

    • Author(s):
    • The World Bank
    • Total pages:
    • 1

  • Strategic Demand Forecasts

    09 August 2012

    Pneumo Strategic Demand Forecast - Version 5_0 – Published 13 August 2012

    ACCELERATE VACCINE INTRODUCTION – PNEUMOCOCCAL CONJUGATE VACCINE Strategic Demand Forecast (Required Supply) Version 5.0 – updated in March 2012 Published – 13 August 2012 This version 5.0 is issued in accordance with the AVI Forecasting Standard Operating Procedure.

    11 March 2011

    Pneumo SDF version 3.0 – published on 11 March 2011

    This version 3.0 is issued in accordance with the AVI Forecasting Standard Operating Procedure. The forecast captures all AMC‐eligible demand including countries that: introduce with GAVI support, graduate from GAVI support, and are fully self-financed.

    • Total pages:
    • 3
    • Publisher:
    • AMC

    07 August 2009

    Pneumo SDF version 0.1 – published on 7 August 2009

    This version 0.1 is issued in accordance with the AVI Forecasting Standard Operating Procedure that foresees the possibility for intermediate updates between official versions when changes in demand exceed predefined thresholds. 

    • Total pages:
    • 2
    • Publisher:
    • GAVI

    12 June 2009

    Pneumo SDF version 0 – published on 12 June 2009

    Pneumococcal vaccine strategic demand forecast corresponding to AMC required supply.

    • Total pages:
    • 1
    • Publisher:
    • GAVI

  • Supporters of the AMC

    09 February 2007

    Bill and Melinda Gates Foundation - Statement of Support

    Statement from the Bill and Melinda Gates foundation announcing support for the pneumococcal AMC.

    • Total pages:
    • 1
    • Publisher:
    • Gates

    01 October 2009

    Case Studies for Global Health - The World’s First Advance Market Commitment

    A case study on the multi-sector effort to build a financing mechanism, the AMC, as an incentive to facilitate vaccine development.

    • Total pages:
    • 7
    • Publisher:
    • Alliance for Case Studies for Global Health

    09 February 2007

    IFPMA Press Release in support of AMC Launch

    The International Federation of Pharmaceutical Manufacturers & Associations (IFPMA) welcomes the public commitment made by the governments of Canada, Italy, Norway and the United Kingdom to fund the pilot Advance Market Commitment (AMC) to stimulate the development of new pneumococcal vaccines for the poorest countries.

    • Total pages:
    • 2
    • Publisher:
    • International Federation of Pharmaceutical Manufacturers and Associations

    09 February 2007

    Pope Address at Vaccine Project Launch

    The address Pope Benedict XVI gave to the representatives of the Advance Market Commitment in Rome, Italy on 9 February 2007.

    • Total pages:
    • 1
    • Publisher:
    • Libreria Editrice Vaticana

    09 February 2007

    Remarks by Her Majesty Queen Rania of Jordan on the AMC Launch 2007

    Remarks of Her Majesty Queen Rania Al-Abdullah on the announcement of Advanced Market Commitments of $1.5 billion in Rome, Italy on 9 February 2007.

    • Total pages:
    • 2
    • Publisher:
    • AMC

  • Target Product Profile (TPP) for Pneumococcal Conjugate Vaccines

    01 September 2010

    Serotype Replacement Note - Prepared by the IAC

    The serotype replacement issue arises from extensive use of pneumococcal conjugate vaccine, which is expected to result in some increase of disease occurence due to serotypes not in the vaccine. This raises question whether the increases could reach a point where the benefit of the vaccine is lost, or the increases will be small relative to the decline in vaccine type disease.

    • Total pages:
    • 4
    • Publisher:
    • AMC

    30 November 2008

    TPP Codebook

    Codebook to assess whether a pneumococcal vaccine meets the Pneumococcal AMC Target Product Profile for regional vaccine serotype coverage.

    • Total pages:
    • 38
    • Publisher:
    • PneumoADIP

    18 December 2008

    TPP Master Table

    The master table of the target product profile (TPP), product specifications, relate to the public health impact and suitability of the product. 

    • Total pages:
    • 2
    • Publisher:
    • AMC

    18 December 2008

    TPP Supplementary Information

    Supplementary informational for the target product profile (TPP) including general information, vaccine characteristics relevant to the TPP, contributors and WHO policy documents. 

    • Total pages:
    • 39
    • Publisher:
    • WHO

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